Publications

Key Publications

• URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats
  BJU Int.
• Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine
  Neurobiol Dis
• The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model
  Inflammation
• Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats
  J Pharm Pharmacol
• Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier
  Br J Pharmacol
• Effects of peripheral FAAH blockade on NTG-induced hyperalgesia–evaluation of URB937 in an animal model of migraine
  Cephalalgia
• The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system
  Pharmacol Res
• Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model
  J Surg Res
• Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions
  Pharmacol Res
• Front and hind paw differential analgesic effects of amitriptyline, gabapentin, ibuprofen, and URB937 on mechanical and cold sensitivity in cisplatin-induced neuropathy
  Mol Pain
• Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats
  Naunyn Schmiedebergs Arch Pharmacol
• Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition
  Exp Neurol
• Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors
  Br J Pharmacol
• Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
  J Pharmacol Exp Ther
• Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro
  Pharmacol Res
• Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
  Nat Neurosci
• Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat
  J Urol
• Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment
  Pharmacol Res
• Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context
  Neuropharmacology
• Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive
  Pharmacol Res
• Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies
  Ann Palliat Med
• FAAH inhibition as a preventive treatment for migraine: A pre-clinical study
  Neurobiol Dis
• Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain
  Pharmacol Res
• Peripheral and spinal activation of cannabinoid receptors by joint mobilization alleviates postoperative pain in mice
  Neuroscience
• Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice
  Br J Pharmacol
• Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
  Scand J Pain
• Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors
  J Med Chem
• The role of the endocannabinoid system in the antihyperalgesic effect of Cedrus atlantica essential oil inhalation in a mouse model of postoperative pain
  J Ethnopharmacol
• Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
  Brain Behav Immun
• Pharmacological characterisation of the CB1 receptor antagonist activity of cannabidiol in the rat vas deferens bioassay
  Eur J Pharmacol