URB937, a peripherally restricted inhibitor for fatty acid amide hydrolase, reduces prostaglandin E2 -induced bladder overactivity and hyperactivity of bladder mechano-afferent nerve fibres in rats
BJU Int.

Characterization of the peripheral FAAH inhibitor, URB937, in animal models of acute and chronic migraine
Neurobiol Dis

The Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates Radiation-Induced Lung Injury in a Mouse Model
Inflammation

Pharmacokinetics, pharmacodynamics and safety studies on URB937, a peripherally restricted fatty acid amide hydrolase inhibitor, in rats
J Pharm Pharmacol

Pharmacological characterization of the peripheral FAAH inhibitor URB937 in female rodents: interaction with the Abcg2 transporter in the blood-placenta barrier
Br J Pharmacol

Effects of peripheral FAAH blockade on NTG-induced hyperalgesia–evaluation of URB937 in an animal model of migraine
Cephalalgia

The ABC membrane transporter ABCG2 prevents access of FAAH inhibitor URB937 to the central nervous system
Pharmacol Res

Posttreatment With the Fatty Acid Amide Hydrolase Inhibitor URB937 Ameliorates One-Lung Ventilation-Induced Lung Injury in a Rabbit Model
J Surg Res

Peripheral FAAH inhibition causes profound antinociception and protects against indomethacin-induced gastric lesions
Pharmacol Res

Front and hind paw differential analgesic effects of amitriptyline, gabapentin, ibuprofen, and URB937 on mechanical and cold sensitivity in cisplatin-induced neuropathy
Mol Pain

Fatty acid amide hydrolase inhibition normalises bladder function and reduces pain through normalising the anandamide/palmitoylethanolamine ratio in the inflamed bladder of rats
Naunyn Schmiedebergs Arch Pharmacol

Synergistic antinociceptive effects of concomitant NAAA and peripheral FAAH inhibition
Exp Neurol

Suppression of acute and anticipatory nausea by peripherally restricted fatty acid amide hydrolase inhibitor in animal models: role of PPARα and CB1 receptors
Br J Pharmacol

Brain-Permeant and -Impermeant Inhibitors of Fatty Acid Amide Hydrolase Synergize with the Opioid Analgesic Morphine to Suppress Chemotherapy-Induced Neuropathic Nociception Without Enhancing Effects of Morphine on Gastrointestinal Transit
J Pharmacol Exp Ther

Brain permeant and impermeant inhibitors of fatty-acid amide hydrolase suppress the development and maintenance of paclitaxel-induced neuropathic pain without producing tolerance or physical dependence in vivo and synergize with paclitaxel to reduce tumor cell line viability in vitro
Pharmacol Res

Anandamide suppresses pain initiation through a peripheral endocannabinoid mechanism
Nat Neurosci

Inhibition of peripheral FAAH depresses activities of bladder mechanosensitive nerve fibers of the rat
J Urol

Alterations in endocannabinoid tone following chemotherapy-induced peripheral neuropathy: effects of endocannabinoid deactivation inhibitors targeting fatty-acid amide hydrolase and monoacylglycerol lipase in comparison to reference analgesics following cisplatin treatment
Pharmacol Res

Supra-spinal FAAH is required for the analgesic action of paracetamol in an inflammatory context
Neuropharmacology

Peripheral FAAH and soluble epoxide hydrolase inhibitors are synergistically antinociceptive
Pharmacol Res

Modulating the endocannabinoid pathway as treatment for peripheral neuropathic pain: a selected review of preclinical studies
Ann Palliat Med

FAAH inhibition as a preventive treatment for migraine: A pre-clinical study
Neurobiol Dis

Structural determinants of peripheral O-arylcarbamate FAAH inhibitors render them dual substrates for Abcb1 and Abcg2 and restrict their access to the brain
Pharmacol Res

Peripheral and spinal activation of cannabinoid receptors by joint mobilization alleviates postoperative pain in mice
Neuroscience

Inhibition of fatty acid amide hydrolase in the CNS prevents and reverses morphine tolerance in male and female mice
Br J Pharmacol

Synergistic combinations of the dual enkephalinase inhibitor PL265 given orally with various analgesic compounds acting on different targets, in a murine model of cancer-induced bone pain
Scand J Pain

Synthesis and structure-activity relationship studies of O-biphenyl-3-yl carbamates as peripherally restricted fatty acid amide hydrolase inhibitors
J Med Chem

The role of the endocannabinoid system in the antihyperalgesic effect of Cedrus atlantica essential oil inhalation in a mouse model of postoperative pain
J Ethnopharmacol

Pharmacological inhibition of FAAH modulates TLR-induced neuroinflammation, but not sickness behaviour: An effect partially mediated by central TRPV1
Brain Behav Immun

Pharmacological characterisation of the CB1 receptor antagonist activity of cannabidiol in the rat vas deferens bioassay
Eur J Pharmacol