Our Differentiated Approach for the Treatment of Chronic Cough, a Neuronal Hypersensitivity Disorder
We are leveraging innovative science and research pioneered by our team and other academic labs to reduce neuronal hypersensitivity and address a number of chronic conditions, including chronic cough. It has been demonstrated that by increasing the levels of anandamide, a naturally occurring compound responsible for a number of functions throughout the body, including sensory and pain modulation, we can desensitize overactive sensory neurons. We can achieve increased levels of anandamide by inhibiting the FAAH enzyme.
The FAAH enzyme breaks down the naturally occurring anandamide. The inhibition of FAAH by EX937 results in elevated anandamide levels and reduced receptor signaling. We have demonstrated profound analgesic effects in a variety of animal models of nociceptive, inflammatory and neurogenic pain, indicating it will have broad clinical application and commercial potential.
Learn More About Our Lead Program EX937