Mechanism of Action in Cough

The URB937 drug is excluded from the brain by a transporter with a pharmacology resembling BCRP, but is free to act on peripheral FAAH. In chronic cough, the site of action is predicted to be the vagal sensory nerve. Here inhibition of FAAH-catalyzed metabolism of anandamide allows for persistent activation of the CB1 receptors, which limits Vagus nerve activation and the cough reflex.

Key Scientific URB937 Publications

A list of published, peer-reviewed URB937 studies, including work from international, academic research laboratories, can be found here.

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